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Zactran Gets M. bovis Labeling

Zactran Gets M. bovis Labeling

New label gives antimicrobial Zactran viable first-pull treatment for all major pathogens of BRD.

Merial just announced Zactran (gamithromycin) is now approved for the treatment of Mycoplasma bovis.

M. bovis is an infectious agent associated with clinical cases of BRD and costs the beef industry nearly $1 billion in death loss, reduced feed efficiency and increased treatment costs. Zactran is Merial's rapid-response weapon in the battle against Bovine Respiratory Disease (BRD) in high-risk cattle,

This approval makes prescription Zactran labeled as a first-pull treatment for all major pathogens of BRD in beef and non-lactating dairy cattle, including Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and M. bovis.

MORE CONTROL: Zactran (gamithromycin) is now approved for the treatment of Mycoplasma bovis.

In addition, ZACTRAN is labeled to control respiratory disease in beef and non-lactating dairy cattle which have high risk of developing BRD associated with M. haemolytica and P. multocida.

Veterinarian Bruce Nosky, manager of Merial Large Animal Veterinary Services, says BRD is a complex disease often involving a calf's immune system, stressors, virus infection, and one or more bacterial pathogens.

"It is not uncommon to have mixed bacterial infections resulting in BRD, which is why it's so important to use a broad-spectrum antimicrobial," Nosky says. "Veterinarians and producers need cattle to respond quickly to treatment, and they can be confident in Zactran."

In field studies conducted for the initial product approval, cattle treated with Zactran showed a rapid improvement in BRD clinical signs. More than three-quarters of the cattle with a fever had a significant decrease in temperature within 24 hours. The majority of cattle treated with Zactran remained healthy throughout the 10-day study.

In additional field trials for BRD control the majority of lightweight, long-haul and high-risk cattle that received Zactran on arrival to control BRD showed significantly less disease during the 10-day study compared to non-treated calves.

Zactran is a prescription product and is administered subcutaneously at a dose of 2 mL per 110 pounds. It is available in three ready-to-use sizes — 100, 250 and 500 mL.

Producers can learn more about ZACTRAN by contacting their veterinarian or visiting

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