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Mixed Results in FDA's Annual Antibiotic Resistance Survey

Mixed Results in FDA's Annual Antibiotic Resistance Survey

FDA finds positive and negative trends in antimicrobial resistance in bacteria isolated from humans, retail meats and food animals

The Food and Drug Administration on Monday released its National Antimicrobial Resistance Monitoring System 2011 Executive Report, showing both increasing and decreasing antimicrobial resistance trends.

The report, established in 1996 as a partnership between the FDA, the Centers for Disease Control and Prevention and the U.S. Department of Agriculture, tracks antibiotic resistance in foodborne bacteria.

The Executive Report summarizes data previously released by each of the three agencies, focusing on resistance to antibiotics that are considered important in human medicine as well as multidrug resistance – resistance to three or more classes of antibiotics.

FDA finds positive and negative trends in antimicrobial resistance in bacteria isolated from humans, retail meats and food animals

Related: Meat Institute Survey Finds Confusion Among Consumers Regarding Antibiotics

Under the NARMS program, samples are collected from human, food producing animals and retail meat sources, and tested for certain bacteria, specifically non-typhoidal Salmonella, Campylobacter and Enterococcus, to determine whether such bacteria are resistant to various antibiotics used in human and veterinary medicine. The report also includes data on Escherichia coli found in retail meats and chickens.

Key findings from the NARMS 2011 Executive Report include:

• Eighty-five percent of non-typhoidal Salmonella collected from humans had no resistance to any of the antibiotics tested.

• In people, the five-drug resistance pattern "ACSSuT" (resistance to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline) in Salmonella Typhimurium has declined to 19.5% in 2011 from its peak in 1997 at 35.1%.

More Antibiotic Resistance survey results >>


• During its 16-year history, NARMS has found Salmonella resistance to ciprofloxacin, one of the most common antibiotics to treat Salmonella infections in humans, to be very low (less than 0.5% in humans, less than 3% in retail meat, and less than 1% in animals at slaughter).

• Multi-drug resistance in Salmonella from humans, slaughtered chickens and slaughtered swine was the lowest since NARMS testing began. However, multi-drug resistance in Salmonella from retail poultry meats generally increased, with slight fluctuations.

Related: Animal Pharmaceutical Companies Commit To FDA's Antibiotic Guidance

• Erythromycin resistance in Campylobacter jejuni (C. jejuni) has remained at less than 4% in isolates obtained from humans, retail chicken and slaughtered chicken since testing began. The antibiotic erythromycin is the drug of choice for treating Campylobacter infections, more than 90% of which are caused by C. jejuni.

• Campylobacter resistance to the fluoroquinolone ciprofloxacin has increased slightly in isolates from humans since 2005. Ciprofloxacin is not approved for use in poultry, and FDA withdrew approval for the use of enrofloxacin in poultry in 2005. Ciprofloxacin and enrofloxacin are both in the same class of drugs (fluoroquinolone).

• Resistance to third-generation cephalosporins, another important drug class for the treatment of Salmonella infections, rose among isolates from retail ground turkey between 2008 and 2011 and among certain Salmonella serotypes in cattle between 2009 and 2011.

In April 2012, FDA prohibited certain uses of cephalosporin drugs in cattle, swine, chickens, and turkeys. NARMS will continue to monitor these trends over time.

"Monitoring antimicrobial resistance through NARMS is an important component of the overall effort to minimize antimicrobial resistance and promote appropriate and judicious use of antimicrobial drugs in both humans and animals," an FDA statement noted.

While some encouraging trends were observed, these findings underscore the need for continued efforts to curb antimicrobial resistance, FDA said.

View previous National Antimicrobial Resistance Monitoring System reports online.

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