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Gene editing in beef cattle: The possibilities could be endless

CRISPR technology-- another tool in the toolbox?

Mark Z. Johnson, Oklahoma State University, Exten Beef Cattle Breeding Specialist

June 6, 2024

1 Min Read
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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a powerful tool for editing genomes. It allows researchers to easily alter DNA sequences and modify gene function. These “intended alterations” accomplished through editing are another potential tool in the tool box of cattle breeders. This technology is primarily useful for simply inherited traits (influenced at one locus of the genome).

 Technology possibilities

CRISPR technology has many potential applications that facilitate sustainability, animal welfare and efficiency. These include:

-       The opportunity to repair deleterious genetic conditions

-       The opportunity to introduce naturally occurring useful alleles into breed germplasm. Specifically, to potentially bring a useful gene from one breed to another breed.

-       Introduce traits that change sex ratio of heifers versus bulls.

-       Enable breeding schemes to accelerate genetic progress

-       Gene edits for disease resistance

 

Gene editing accomplishments

As of now, the successful gene edits accomplished in cattle include:

-       The first gene edited beef calf with reduced susceptibility to a major viral pathogen, Bovine Viral Diarrhea Virus (BVDV)

-       Knock out of the Myostatin gene to increase lean muscle yield

-       Intraspecies Polled allele substitution

-       Intraspecies Slick hair allele and gene for diluted coat color to improve heat tolerance

 

The use of this technology in the United States beef industry likely hinges on the regulatory framework imposed. On a global basis, this varies dramatically from country to country. The future of genome editing will likely be governed by the development of a fit-for-purpose, risk-based regulatory framework that fosters innovation, supports trade, creates profit potential and promotes public acceptance. 

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